Local Immunodeficiency: Combining Cross-Immunoreactivity Networks
- 1 April 2023
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Computational Biology
- Vol. 30 (4), 492-501
- https://doi.org/10.1089/cmb.2022.0390
Abstract
This article continues the analysis of the recently observed phenomenon of local immunodeficiency (LI), which arises as a result of antigenic cooperation among intrahost viruses organized into a network of cross-immunoreactivity (CR). We study here what happens as the result of combining (connecting) the simplest CR networks, which have a stable state of LI. It turned out that many possibilities occur, particularly resulting in a change of roles of some viruses in the CR network. Our results also give some indications about a boundary of the set of CR networks with stable state of LI in the entire collection of all possible CR networks. Such borderline CR networks are characterized by only a marginally stable (neutral rather than stable) state of the LI, or by the existence of such subnetworks in a CR network that evolve independently of each other (although being connected).This publication has 15 references indexed in Scilit:
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