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In depth investigation of analytical methods for the determination of montelukast and bilastine in biological fluid and pharmaceutical dosage forms: A Review

Pinkal Patel, Zinal A. Panchal, Sweta Patel, Dipti Patel

Abstract: Allergic rhinitis (AR) is a heterogeneous disorder that despite its high prevalence is often undiagnosed. It is characterized by one or more symptoms including sneezing, itching, nasal congestion and rhinorrhea. Many causative agents have been linked to allergic rhinitis (AR) including pollens, molds, dust mites and animal dander allergy. Montelukast and bilastine are used in the treatment of allergic rhinitis (AR). Montelukast and bilastine each drug reveals in vivo and in vitro. They are generally administrated as tablets. Determination of montelukast and bilastine in bulk dosage form, tablet dosage form and pharmaceutical dosage form. Method indicating human plasma stability and impurity profiling are also described for Montelukast and Bilastine drugs. Several analytical methods including UV, HPTLC and HPLC method has been developed. Estimation of montelukast and bilastine for quantitative and qualitative method can be used. In this review methods for determination of montelukast and bilastine in alone and in combination by UV and RP-HPLC techniques. This review covers most recent analytical methods such as various spectroscopic methods, chromatographic methods and other methods for determination of Montelukast and Bilastine in various pharmaceutical dosage forms. The following study illustrate the review on analytical method which includes estimating the anti-histamines drugs.
Keywords: pharmaceutical dosage forms / montelukast and bilastine / HPLC / tablet / analytical

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