New Search

Export article
Open Access

Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues

, Sandra C. A. Nielsen, Ramona A. Hoh, , Oliver Fabian Wirz, Emily Haraguchi, Grace H. Jean, Ji-Yeun Lee, Tho D. Pham, , Krishna M. Roskin, Yi Liu, Khoa Nguyen, , Eleanor M. Osborne, , Claus U. Niemann, ,
Science ; doi:10.1126/science.abf6648

Abstract: Vaccination and infection promote the formation, tissue distribution, and clonal evolution of B cells, which encode humoral immune memory. We evaluated convergent antigen-specific antibody genes of similar sequences shared between individuals in pediatric and adult blood, and deceased organ donor tissues. B cell memory varied for different pathogens. Polysaccharide antigen-specific clones were not exclusive to the spleen. Adults had higher clone frequencies and greater class-switching in lymphoid tissues than blood, while pediatric blood had abundant class-switched convergent clones. Consistent with reported serology, pre-pandemic children had class-switched convergent clones to SARS-CoV-2 with weak cross-reactivity to other coronaviruses, while adult blood or tissues showed few such clones. The results highlight the prominence of early childhood B cell clonal expansions and cross-reactivity for future responses to novel pathogens.
Keywords: evolution / tissues / adult / antigen / clones / children / antibody / Vaccination / coronaviruses / switched

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

Share this article

Click here to see the statistics on "Science" .
References (83)
    Back to Top Top