Insulin-Like Growth Factor, Inflammation, and MRI Markers of Alzheimer’s Disease in Predominantly Middle-Aged Adults
- 17 May 2022
- journal article
- research article
- Published by IOS Press in Journal of Alzheimer's Disease
- Vol. 88 (1), 311-322
- https://doi.org/10.3233/jad-220356
Abstract
Background: Insulin-like growth factor 1 (IGF-1) signaling has been implicated in Alzheimer’s disease pathogenesis, and further evidence suggests inflammation can be a moderator of this association. However, most research to date has been conducted oKeywords
This publication has 56 references indexed in Scilit:
- Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive declineJCI Insight, 2012
- C-reactive protein is related to memory and medial temporal brain volume in older adultsBrain, Behavior, and Immunity, 2012
- Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical LiteratureCold Spring Harbor Perspectives in Medicine, 2011
- Circulating Insulin-Like Growth Factor-1 and Its Binding Protein-3Arteriosclerosis, Thrombosis, and Vascular Biology, 2010
- Cohort Profile: The Study of Health in PomeraniaInternational Journal of Epidemiology, 2010
- Insulinlike Growth Factor‐1, Insulinlike Growth Factor Binding Protein‐1, and Cognitive Function in Older Men and WomenJournal of the American Geriatrics Society, 2009
- Multi-atlas based segmentation of brain images: Atlas selection and its effect on accuracyNeuroImage, 2009
- Growth hormone secretagogue MK-677Neurology, 2008
- Computer-Assisted Segmentation of White Matter Lesions in 3D MR Images Using Support Vector MachineAcademic Radiology, 2008
- The framingham offspring study. Design and preliminary dataPreventive Medicine, 1975