Editorial on the Research Topic Polymer Chemistry Editor’s Pick 2021 The section Polymer Chemistry of the journal Frontiers in Chemistry was born with the scope of witnessing, disseminating and fostering the advancements of the discipline of macromolecular science in its broadest significance. The opening of a specific section devoted entirely to this subject was justified by the profound impact this discipline and the outcomes of its research efforts have had and continue to have on our everyday life. As stated in the inaugural article (Musto) “Despite the astonishing achievements we have witnessed along the years, many exciting challenges remain to be faced, including green polymer chemistry, environmental pollution issues, polymers for energy storage and delivery, polymers for the human health.” Seven years after its launch, we may say that, so far, the section has accomplished the tasks it was created for. The readership is growing, as well as the community of editors and qualified authors. Many interesting papers have appeared, addressing the most relevant challenges currently open, with special emphasis on health related issues. It was therefore decided, according with the editorial office, that the time was mature to realize a Research Topic, assembling a collection of articles that could give to the reader an outlook of the section activity and a summary of its main achievements. The choice among the numerous high-quality contributions was not easy; it was driven by the limited number of articles to be included (thirteen), the readership acceptance as evaluated by the significant bibliometric figures made available by the journal platform and, of course, the personal taste of the Editor, of which he takes full responsibility. The work presented herein witnesses the broad range of activities covered by the section and demonstrates strong advances in theory, experiment and methodology applied to forefront research challenges. The first contribution Si et al. deals with the development of an innovative hydrogel to be used for selective removal of aromatic pollutants from wastewater. This stimuli-responsive, molecularly imprinted material was characterized by spectroscopic and electron microscopy means and was investigated in terms of adsorption and selective recognition of substituted phenols. It was demonstrated that the hydrogel has good selectivity, temperature switching properties, and is reusable, which makes it a good candidate for controlled separation and release of phenolic pollutants. In the second paper Ding et al. is described the synthesis of chitosan grafted by β-cyclodextrin. This functional material exhibited strong antimicrobial activity against E. coli and Staphylococcus xylosus, which was tuned by adjusting the amino content of the polysaccharide. The reported results may be relevant in the livestock industry as a means of reducing the dosage of antibiotics and the antibiotic residues in animal-derived foods. Next, Galizia and Bye present a detailed review on organic solvent nanofiltration, highlighting the relationship among this process and the underlying physical-chemistry and polymer chemistry. In the first part of the review are discussed the available theoretical models, along with some misleading conclusions commonly encountered in the literature. The following section describes the most conventional materials currently in use and identifies a number of alternative materials that may impact this technology in the near future. The work by Pizarro et al. is an excellent example of the application of precision synthetic routes, in particular, atom-transfer radical polymerization (ATRP), to finely control the surface properties of polymer films. It was demonstrated that parameters such as pore size, roughness, thickness, and wettability of a co-polymer film could be varied by changing the co-monomer structures. Moreover, thermal annealing was found to improve significantly the surface quality, thus providing a further means toward surface engineering. The review article by Yao et al. is an account of current research on polymer-based composites to be used as electrolytes in Lithium batteries. This is a relevant technological challenge, since substitution of the conventional liquid electrolytes currently in use with solid-state components may allow to overcome numerous weaknesses of Li-ion cells. The survey describes in detail the main classes of composites under consideration, with the relative conductivity mechanisms. The fundamental issues still unsolved are critically discussed. The research paper by Quigley et al. concerns a relevant health issue, namely the repairing of Volumetric Muscle Loss (VML) as a consequence of trauma (road/industrial accident, war injury) or disease (muscular dystrophy, muscle atrophy). The authors report an innovative biosynthetic material based on the “Trojan Horse” concept. It is an alginate/myoblast construct that was tested successfully as a scaffold for remodelling of diseased and/or damaged muscle. The work by Talebian et al. deals with electrically conductive hydrogels to be used as biofibers for in-vivo stimulation of electrically excitable cells. The biofibers were realized by electrospinning of an alginate/graphene nanocomposite. The graphene-additivated biofibers exhibited better mechanical, electrical and electrochemical properties in comparison to the pristine fibers. In the light of the results obtained, they were also proposed as 3D scaffolds for tissue engineering applications. Light-responsive materials, e.g., materials that exhibit on-off switching properties when irradiated at specific frequencies, are a hot-topic for an increasing number of high-tech applications. The paper by Pang et al. reports on the realization and the morphological/spectroscopic characterization of one of such systems based on...