Gut related inflammation and cardiorespiratory fitness in patients with CAD and type 2 diabetes: a sub-study of a randomized controlled trial on exercise training
Open Access
- 1 April 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Diabetology & Metabolic Syndrome
- Vol. 13 (1), 1-9
- https://doi.org/10.1186/s13098-021-00655-2
Abstract
Gut leakage has been shown to associate with low-grade inflammation and lower cardiorespiratory fitness in diabetic subjects. We aimed to investigate whether gut leakage markers related to cardiorespiratory fitness in patients with both coronary artery disease and type 2 diabetes, and whether these were affected by long-term exercise training. Patients with angiographically verified coronary artery disease and type 2 diabetes mellitus (n = 137) were randomized to either 12 months exercise intervention or conventional follow-up. A cardiopulmonary exercise test and fasting blood samples were obtained before and after intervention to assess VO2peak and the biomarkers soluble CD14, lipopolysaccharide-binding protein and intestinal fatty-acid binding protein as markers of gut leakage. 114 patients completed the intervention satisfactory. VO2peak correlated inversely to sCD14 (r = − 0.248, p = 0.004) at baseline. Dividing sCD14 into quartiles (Q), VO2peak was significantly higher in Q1 vs. Q2–4 (p = 0.001), and patients in Q2-4 (sCD14 > 1300 ng/mL) had an OR of 2.9 (95% CI 1.2–7.0) of having VO2peak below median (< 23.8 ml/kg/min) at baseline. There were no statistically significant differences in changes in gut leakage markers between the two randomized groups (all p > 0.05) after 12 months. Cardiorespiratory fitness related inversely to sCD14, suggesting physical capacity to be associated with gut leakage in patients with CAD and T2DM. Long-term exercise training did not affect circulating gut leakage markers in our population. Trial registration NCT01232608, Registered 02 November 2010—Retrospectively registered at https://clinicaltrials.gov/ct2/show/NCT01232608?term=NCT01232608&draw=2&rank=1Keywords
Funding Information
- Ada og Hagbart Waages Humanitære og Veldedige Stiftelse
- Stein Erik Hagen Foundation for Clinical Heart Research
This publication has 31 references indexed in Scilit:
- Inflammation as a link between obesity, metabolic syndrome and type 2 diabetesDiabetes Research and Clinical Practice, 2014
- Insulin levels and HOMA index are associated with exercise capacity in patients with type 2 diabetes and coronary artery diseaseDiabetology & Metabolic Syndrome, 2014
- Soluble CD14Arteriosclerosis, Thrombosis, and Vascular Biology, 2013
- Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemiaBritish Journal of Nutrition, 2012
- Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistanceInternational Journal of Obesity, 2011
- Exercise Training for Type 2 Diabetes MellitusJournal of the American College of Cardiology, 2009
- Association of Lipopolysaccharide-Binding Protein and Coronary Artery Disease in MenJournal of Invasive Cardiology, 2007
- Use and Abuse of HOMA ModelingDiabetes Care, 2004
- Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14.Proceedings of the National Academy of Sciences of the United States of America, 1993
- Perceived ExertionExercise and Sport Sciences Reviews, 1974