Interaction of 9-Methoxyluminarine with Different G-Quadruplex Topologies: Fluorescence and Circular Dichroism Studies
Open Access
- 27 September 2021
- journal article
- research article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 22 (19), 10399
- https://doi.org/10.3390/ijms221910399
Abstract
The interactions of G–quadruplexes of different topologies with highly fluorescent 9-methoxyluminarine ligand 9-MeLM were investigated by fluorescence and circular dichroism spectroscopy. The results showed that 9-methoxyluminarine was able to interact and did not destabilize any investigated molecular targets. The studied compound was selectively quenched by parallel c-MYC G-quadruplex DNA, whereas hybrid and antiparallel G4 topology caused only a negligible decrease in the fluorescence of the ligand. A high decrease of fluorescence of the ligand after binding with c-MYC G-quadruplex suggests that this molecule can be used as a selective probe for parallel G-quadruplexes.This publication has 79 references indexed in Scilit:
- Solution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug DesignJournal of the American Chemical Society, 2011
- Diarylethynyl Amides That Recognize the Parallel Conformation of Genomic Promoter DNA G-QuadruplexesJournal of the American Chemical Society, 2008
- A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at TelomeresJournal of the American Chemical Society, 2008
- A hitchhiker's guide to G-quadruplex ligandsOrganic & Biomolecular Chemistry, 2007
- An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translationNature Chemical Biology, 2007
- Quadruplex DNA: sequence, topology and structureNucleic Acids Research, 2006
- QGRS Mapper: a web-based server for predicting G-quadruplexes in nucleotide sequencesNucleic Acids Research, 2006
- A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit OncogeneBiochemistry, 2006
- Deconvoluting the Structural and Drug-Recognition Complexity of the G-Quadruplex-Forming Region Upstream of the bcl-2 P1 PromoterJournal of the American Chemical Society, 2006
- Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solutionNucleic Acids Research, 2006