Persistent 3′-phosphate termini and increased cytotoxicity of radiomimetic DNA double-strand breaks in cells lacking polynucleotide kinase/phosphatase despite presence of an alternative 3′-phosphatase
- 1 August 2018
- journal article
- research article
- Published by Elsevier BV in DNA Repair
- Vol. 68, 12-24
- https://doi.org/10.1016/j.dnarep.2018.05.002
Abstract
No abstract availableKeywords
Funding Information
- National Cancer Institute, USDHHS (CA40615, CA166264)
- Canadian Institutes of Health Research (MOP 15385)
- Alberta Cancer Foundation Transformative Program Project (26603)
This publication has 47 references indexed in Scilit:
- Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phaseNucleic Acids Research, 2012
- DNA Repair Factor MRE11/RAD50 Cleaves 3′-Phosphotyrosyl Bonds and Resects DNA to Repair Damage Caused by Topoisomerase 1 PoisonsOnline Journal of Public Health Informatics, 2011
- Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repairTrends in Biochemical Sciences, 2011
- Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cellsProceedings of the National Academy of Sciences of the United States of America, 2011
- Sensitization to Radiation and Alkylating Agents by Inhibitors of Poly(ADP-ribose) Polymerase Is Enhanced in Cells Deficient in DNA Double-Strand Break RepairMolecular Cancer Therapeutics, 2010
- PARP inhibition: PARP1 and beyondNature Reviews Cancer, 2010
- ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2The EMBO Journal, 2009
- Requirement for XLF/Cernunnos in alignment-based gap filling by DNA polymerases λ and μ for nonhomologous end joining in human whole-cell extractsNucleic Acids Research, 2009
- Phosphorylation in the serine/threonine 2609–2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extractsNucleic Acids Research, 2007
- DNA strand scission by the antitumor protein neocarzinostatinBiochemical and Biophysical Research Communications, 1974