Diagnostic utility of FGF-23 in mineral bone disorder during chronic kidney disease
Open Access
- 8 January 2022
- journal article
- Published by Aboutscience Srl in Journal of Circulating Biomarkers
- Vol. 11, 1-4
- https://doi.org/10.33393/jcb.2022.2328
Abstract
Our data confirm that intact fibroblast growth factor 23 (iFGF-23) concentration is increased in patients with chronic kidney disease (CKD) and that it increases with disease progression (stages I-V). Therefore, iFGF-23 could be considered an early biomarker in the course of chronic kidney disease-mineral bone disorder (CKD-MBD), which has several aspects that make it potentially useful in clinical practice. The availability of an automated method for iFGF-23 assay may represent an added value in the management of the patient with CKD-MBD already from the early stages of the disease, before the increase of the routinely used laboratory parameters, 1-84 parathyroid hormone (PTH) and 25-OH-vitamin D (25-OH-vitD), which occur in more advanced stages of the disease.Keywords
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