Objective assessment of impulse control disorder in patients with Parkinson’s disease using a low-cost LEGO-like EEG headset: a feasibility study
Open Access
- 2 July 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of NeuroEngineering and Rehabilitation
- Vol. 18 (1), 1-12
- https://doi.org/10.1186/s12984-021-00897-1
Abstract
Background: Patients with Parkinson’s disease (PD) can develop impulse control disorders (ICDs) while undergoing a pharmacological treatment for motor control dysfunctions with a dopamine agonist (DA). Conventional clinical interviews or questionnaires can be biased and may not accurately diagnose at the early stage. A wearable electroencephalogram (EEG)-sensing headset paired with an examination procedure can be a potential user-friendly method to explore ICD-related signatures that can detect its early signs and progression by reflecting brain activity. Methods: A stereotypical Go/NoGo test that targets impulse inhibition was performed on 59 individuals, including healthy controls, patients with PD, and patients with PD diagnosed by ICDs. We conducted two Go/NoGo sessions before and after the DA-pharmacological treatment for the PD and ICD groups. A low-cost LEGO-like EEG headset was used to record concurrent EEG signals. Then, we used the event-related potential (ERP) analytical framework to explore ICD-related EEG abnormalities after DA treatment. Results: After the DA treatment, only the ICD-diagnosed PD patients made more behavioral errors and tended to exhibit the deterioration for the NoGo N2 and P3 peak amplitudes at fronto-central electrodes in contrast to the HC and PD groups. Particularly, the extent of the diminished NoGo-N2 amplitude was prone to be modulated by the ICD scores at Fz with marginal statistical significance (r = − 0.34, p = 0.07). Conclusions: The low-cost LEGO-like EEG headset successfully captured ERP waveforms and objectively assessed ICD in patients with PD undergoing DA treatment. This objective neuro-evidence could provide complementary information to conventional clinical scales used to diagnose ICD adverse effects.Keywords
Funding Information
- National Sun Yat-sen University (CMRPG8I0371)
- Kaohsiung Chang Gung Memorial Hospital (CMRPG8I0371)
This publication has 68 references indexed in Scilit:
- Differential Go/NoGo Activity in Both Contingent Negative Variation and Spectral PowerPLOS ONE, 2012
- Questionnaire for impulsive‐compulsive disorders in Parkinson's Disease–Rating ScaleMovement Disorders, 2011
- Impulse control disorders in Parkinson’s disease: seeking a roadmap toward a better understandingBrain Structure and Function, 2011
- Dopamine agonists and risk: impulse control disorders in Parkinson's; diseaseBrain, 2011
- Impulse inhibition in people with Internet addiction disorder: Electrophysiological evidence from a Go/NoGo studyNeuroscience Letters, 2010
- Visual working memory deficits in patients with Parkinson's disease are due to both reduced storage capacity and impaired ability to filter out irrelevant informationBrain, 2010
- A novel approach for enhancing the signal-to-noise ratio and detecting automatically event-related potentials (ERPs) in single trialsNeuroImage, 2010
- Neural substrates of the interaction of emotional stimulus processing and motor inhibitory control: An emotional linguistic go/no-go fMRI studyNeuroImage, 2007
- Event-related potentials for response inhibition in Parkinson's diseaseNeuropsychologia, 2005
- Recipes for the linear analysis of EEGNeuroImage, 2005