Vitamin D status and association with gestational diabetes mellitus in a pregnant cohort in Iceland
Open Access
- 23 March 2021
- journal article
- research article
- Published by SNF Swedish Nutrition Foundation in Food & Nutrition Research
Abstract
Background: Vitamin D deficiency has been associated with an increased risk of gestational diabetes mellitus (GDM), one of the most common pregnancy complications. The vitamin D status has never previously been studied in pregnant women in Iceland. Objective: The aim of this research study was to evaluate the vitamin D status of an Icelandic cohort of pregnant women and the association between the vitamin D status and the GDM incidence. Design: Subjects included pregnant women (n = 938) who attended their first ultrasound appointment, during gestational weeks 11–14, between October 2017 and March 2018. The use of supplements containing vitamin D over the previous 3 months, height, pre-pregnancy weight, and social status were assessed using a questionnaire, and blood samples were drawn for analyzing the serum 25‑hydroxyvitamin D (25OHD) concentration. Information regarding the incidence of GDM later in pregnancy was collected from medical records. Results: The mean ± standard deviation of the serum 25OHD (S-25OHD) concentration in this cohort was 63±24 nmol/L. The proportion of women with an S-25OHD concentration of ≥ 50 nmol/L (which is considered adequate) was 70%, whereas 25% had concentrations between 30 and 49.9 nmol/L (insufficient) and 5% had concentrations < 30 nmol/L (deficient). The majority of women (n = 766, 82%) used supplements containing vitamin D on a daily basis. A gradual decrease in the proportion of women diagnosed with GDM was reported with increasing S-25OHD concentrations, going from 17.8% in the group with S-25OHD concentrations < 30 nmol/L to 12.8% in the group with S-25OHD concentrations ≥75 nmol/L; however, the association was not significant (P for trend = 0.11). Conclusion: Approximately one-third of this cohort had S-25OHD concentrations below adequate levels (< 50 nmol/L) during the first trimester of pregnancy, which may suggest that necessary action must be taken to increase their vitamin D levels. No clear association was observed between the vitamin D status and GDM in this study.Keywords
This publication has 27 references indexed in Scilit:
- Retracted: Effects of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation, and oxidative stress in gestational diabetes: a double-blind randomized controlled clinical trialThe American Journal of Clinical Nutrition, 2013
- Determinants of vitamin D status in pregnant fair-skinned women in SwedenBritish Journal of Nutrition, 2013
- A Systematic Review: Influence of Vitamin D Supplementation on Serum 25-Hydroxyvitamin D ConcentrationJournal of Clinical Endocrinology & Metabolism, 2012
- Vitamin D and gestational diabetes: A systematic review and meta-analysisEuropean Journal of Internal Medicine, 2012
- Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectivenessJournal of Bone and Mineral Research, 2011
- Cholecalciferol loading dose guideline for vitamin D-deficient adultsActa Endocrinologica, 2010
- International Association of Diabetes and Pregnancy Study Groups Recommendations on the Diagnosis and Classification of Hyperglycemia in PregnancyDiabetes Care, 2010
- Vitamin D Requirement During Pregnancy and LactationJournal of Bone and Mineral Research, 2007
- Correlation between vitamin D3 deficiency and insulin resistance in pregnancyDiabetes/Metabolism Research and Reviews, 2007
- Relationship Between Serum Parathyroid Hormone Levels, Vitamin D Sufficiency, and Calcium IntakeJAMA, 2005