INCREASING THE SENSITIVITY AND METROLOGICAL RELIABILITY OF A DIFFERENTIAL CONDUCTOMETRIC BIOSENSOR SYSTEM
Open Access
- 21 October 2021
- journal article
- Published by National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications) in Tekhnichna Elektrodynamika
- Vol. 2021 (6), 68-77
- https://doi.org/10.15407/techned2021.06.068
Abstract
The differential method of conductometric measurements does not fully solve the problem of the influence of changes in the background electrical conductivity of the working buffer solutions on the results of conversion of the biosensor responses. The variation in the background electrical conductivity of the buffer solution upon addition of the highly conductive analyte acts as a common mode interference and causes the additive error. Here we present a new measurement method and structure of the device for quantification of the analytes that provide a significant decrease in the measurement error associated with a change in the background electrical conductivity caused by the introduction of the analyte to the working solution prior to the generation of the informative signal. A block diagram of the device and a vector model of the balancing process of its measuring circuit are presented. The advantages of the developed method and biosensor analyzer for application within the possible changes of the transducer parameters and measurement conditions are demonstrated. References 28, figures 4.Keywords
This publication has 34 references indexed in Scilit:
- Conductometric Biosensor Based on Flavocytochrome b2 for L-Lactate DeterminationSensor Letters, 2011
- Conductometric Chemosensors Based on Calixarenes for Determination of Amines and Amino AcidsSensor Letters, 2009
- Determination of Heavy Metal Inos Using Conductometric Biosensor Based on Sol-Gel Immobilized UreaseBulletin of the Korean Chemical Society, 2002
- Sol–gel-derived thick-film conductometric biosensor for urea determination in serumAnalytica Chimica Acta, 2000
- Hydrogen peroxide – sensitive enzyme sensor based on phthalocyanine thin filmAnalytica Chimica Acta, 1999
- Performance of a planar differential-conductivity sensor for ureaSensors and Actuators B: Chemical, 1994
- Electrical conductivity measurements using microfabricated interdigitated electrodesAnalytical Chemistry, 1993
- Chip biosensors on thin-film metal electrodesSensors and Actuators B: Chemical, 1991
- A microelectronic conductimetric biosensorBiosensors, 1988
- Biosensors: fundamentals and applications : OUP, Oxford, 1987 (ISBN 0-19-854724-2). xvi+770 pp. Price £60.00Analytica Chimica Acta, 1987