Background and objectives: The treatment of humeral shaft fractures might include plate osteosynthesis or intramedullary nailing. The fracture hematoma is maintained using intramedullary nails because they are placed in a closed way, allowing for early fracture consolidation and decreased infection rates. Interlocking provides rotational stability, allowing nearby joints to mobilize more quickly. Antegrade nailing, on the other hand, has the side effect of tightening the shoulder. in this study, we wanted to see how humeral shaft fractures treated with closed Antegrade Intramedullary nailing fared in terms of time to union, functional results, and comorbidities. Methods: Twenty adult patients with acute humeral shaft fractures were treated using antegrade closed intramedullary nailing. With an average age of 38.4 yrs., there had been 17 men and 3 females (21-65 yrs.). These patients had tracked for two years as well as the outcomes were assessed. Results: 1 (5%) fracture failed to union after an average consolidation time of 13.78 weeks (11-16 weeks). There were three occurrences of intraoperative fracture comminution (15%) that had no impact on fracture healing. 2 (10%) of the patients experienced nail impingement, 1 (5%) had shoulder stiffness, and 1 (5%) had a superficial infection. Functional outcomes were good in 17 (85%), moderate in 2 (10%), and poor in 1 (5%). Results: 1 (5%) fracture failed to union after an average consolidation time of 13.78 weeks (11-16 weeks). There were three occurrences of intraoperative fracture comminution (15%) that had no impact on fracture healing. 2 (10%) of the patients experienced nail impingement, 1 (5%) had shoulder stiffness, and 1 (5%) had a superficial infection. Functional outcomes were good in 17 (85%), moderate in 2 (10%), and poor in 1 (5%).