Molecular Similarity within Carcinogen and Guanine Cyclic Nucleotide Structures
Open Access
- 1 January 2022
- journal article
- research article
- Published by Scientific Research Publishing, Inc. in Journal of Biosciences and Medicines
- Vol. 10 (05), 86-94
- https://doi.org/10.4236/jbm.2022.105008
Abstract
Tumor promoters, apoptosis and autophagy modulators, chemotherapy drugs, and endogenous steroids demonstrate molecular similarity relative to cyclic nucleotide structure. This study explores relative molecular similarity within established human carcinogen structures using computational chemistry software. Molecular structures of conventional carcinogenic drugs and industrial agents demonstrate molecular similarity with a focus on the guanine base and nucleotide cyclized ring. Structures of volatile and gaseous anesthetic carcinogens do not conform to conventional 3-point pharmacophore-based fits characteristic of receptor-binding drugs. The results of this study provide some insight into how carcinogen structures may interact with endogenous compounds to disrupt cyclic nucleotide-driven homeostatic mechanisms.Keywords
This publication has 20 references indexed in Scilit:
- The Frequency of Ras Mutations in CancerCancer Research, 2020
- General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levelsPLOS ONE, 2018
- Understanding Anesthetic Mechanisms: Analysis of the Complex Kinetics of Ligand-Gated Ion ChannelsPublished by Elsevier BV ,2018
- Calcium-ATPases: Gene disorders and dysregulation in cancerBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016
- Expression and Function of Phosphodiesterase Type 5 in Human Breast Cancer Cell Lines and Tissues: Implications for Targeted TherapyClinical Cancer Research, 2016
- The Molecular Mechanisms of Anesthetic Action: Updates and Cutting Edge Developments from the Field of Molecular ModelingPharmaceuticals, 2010
- Weak Polar Interactions Confer Albumin Binding Site Selectivity for Haloether AnestheticsAnesthesiology, 2005
- Relative Molecular Similarity in Selected Chemical Carcinogens and the Nucleoside Triphosphate ChainBasic & Clinical Pharmacology & Toxicology, 2003
- Na+,K+pump and Na+-coupled ion carriers in isolated mammalian kidney epithelial cells: regulation by protein kinase CCanadian Journal of Physiology and Pharmacology, 1999
- Membrane fluidization by ether, other anesthetics, and certain agents abolishes P‐glycoprotein ATPase activity and modulates efflux from multidrug‐resistant cellsJBIC Journal of Biological Inorganic Chemistry, 1999