Preimplantation genetic diagnosis and the biopsy technique: Important considerations
Open Access
- 1 January 2013
- journal article
- Published by Scientific Research Publishing, Inc. in Advances in Reproductive Sciences
- Vol. 01 (02), 7-14
- https://doi.org/10.4236/arsci.2013.12002
Abstract
Preimplantation genetic diagnosis allows to test the genetic status of embryos prior to implantation. In order to obtain genetic material, on which carry out a genetic diagnosis, a procedure named embryo biopsy is required. In the last two decades, embryo biopsy at the cleavage stage has been the mostly performed procedure. However, recently, alternative methods allowing the retrieval of a larger number of cells (blastocyst stage biopsy), or representing a valid alternative to overcome ethical issues (polar body biopsy) have obtained increasing consensus. This article reviews different methods of embryo biopsy and points out their positive and negative aspects.Keywords
This publication has 50 references indexed in Scilit:
- Preimplantation genetic diagnosis: State of the ART 2011Human Genetics, 2011
- Preimplantation genetic screening: does it help or hinder IVF treatment and what is the role of the embryo?Journal of Assisted Reproduction and Genetics, 2011
- Preimplantation genetic screening for aneuploidy of embryos after in vitro fertilization in women aged at least 35 years: a prospective randomized trialFertility and Sterility, 2010
- The right not to know and preimplantation genetic diagnosis for Huntington's diseaseJournal of Medical Ethics, 2009
- Vitrification of human embryos subjected to blastomere biopsy for pre-implantation genetic screening produces higher survival and pregnancy rates than slow freezingJournal of Assisted Reproduction and Genetics, 2009
- Polar body biopsyPublished by Cambridge University Press (CUP) ,2009
- BackgroundPublished by Cambridge University Press (CUP) ,2009
- Pregnancies and live births after trophectoderm biopsy and preimplantation genetic testing of human blastocystsFertility and Sterility, 2005
- Cytogenetic analysis of human blastocystsPrenatal Diagnosis, 2002
- Preconception and preimplantation diagnosis for cystic fibrosisPrenatal Diagnosis, 1992