An efficient synthesis of some new isolated and fused 2-oxo-2H-chromene derivatives as antimicrobial and antitumor agents

Abstract

An efficient synthesis of the biologically active novel systems derived from the reaction of 4-methyl-2-oxo-2H-chromene-3-carbonitrile (1) with sodium hydroxide and/or DMF-DMA and cyclocondensation reactions of 4-[(E)-2-(dimethylamino)ethenyl]-2-oxo-2H-chromene-3-carbonitrile (5) with nitrogen nucleophilic reagents afforded the corresponding 4-iminochromeno[3,4-c]pyridine derivatives (6-14). The structures of the prepared compounds have been proved by elemental analysis, IR, ¹H and ¹³C NMR and mass spectra. Significant antitumor activities in planta were observed for some of the prepared compounds.