miRNA-223 as a regulator of inflammation and NLRP3 inflammasome, the main fragments in the puzzle of immunopathogenesis of different inflammatory diseases and COVID-19
- 30 September 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 394 (11), 2187-2195
- https://doi.org/10.1007/s00210-021-02163-6
Abstract
Millions of people around the world are involved with COVID-19 due to infection with SARS-CoV-2. Virological features of SARS-CoV-2, including its genomic sequence, have been identified but the mechanisms governing COVID-19 immunopathogenesis have remained uncertain. miR-223 is a hematopoietic cell-derived miRNA that is implicated in regulating monocyte-macrophage differentiation, neutrophil recruitment, and pro-inflammatory responses. The miR-223 controls inflammation by targeting a variety of factors, including TRAF6, IKKα, HSP-70, FOXO1, TLR4, PI3K/AKT, PARP-1, HDAC2, ITGB3, CXCL2, CCL3, IL-6, IFN-I, STMN1, IL-1β, IL-18, Caspase-1, NF-κB, and NLRP3. The key role of miR-223 in regulating the inflammatory process and its antioxidant and antiviral role can suggest this miRNA as a potential regulatory factor in the process of COVID-19 immunopathogenesis.Keywords
This publication has 61 references indexed in Scilit:
- MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitmentJCI Insight, 2013
- MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2Biochemical and Biophysical Research Communications, 2013
- Expression profiles of miRNAs in polarized macrophagesInternational Journal of Molecular Medicine, 2013
- Role of miRNAs in CD4 T cell plasticity during inflammation and toleranceFrontiers in Genetics, 2013
- NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223The Journal of Immunology, 2012
- Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1β ProductionThe Journal of Immunology, 2012
- Physiological and pathological roles for microRNAs in the immune systemNature Reviews Immunology, 2010
- The Inflammasomes: Guardians of the BodyAnnual Review of Immunology, 2009
- Pyroptosis: host cell death and inflammationNature Reviews Microbiology, 2009
- Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?Nature Reviews Genetics, 2008