Relation of Lipoxygenase activity with some biochemical parameters in epilepsy patients

Abstract
Epilepsy is a define as a generally disorder in neurological that affects more than 50 million people in the world, also is referred to as acute encephalitis, or a disorder in its system that leads to an over excitation of nerve tissues. Lipoxygenase [EC 1.13.11.12] catalyzes the bi-oxidation of polyunsaturated fatty acids. This enzyme pathway leads to the production of leukotrienes and fatty acid hydroperoxide that have essential role in many inflammatory diseases such nerve disorders. In this study, 40 samples of epilepsy patients and 60 healthy of both sexes were taken. The activity of the lipoxygenase, polyamine oxidase and lipid profile triacylglycerol, total cholesterol, high density lipoprotein, low density lipoprotein and very low-density lipoprotein in addition to the level of glucose, uric acid, albumin, bilirubin and total protein as well as the level of vitamin E and C, malondialdehyde and glutathione were measured. The results illustrate a significant increase in of Lipoxygenase glucose, uric acid, albumin and insignificant for polyamine oxidase, bilirubin and total protein in epilepsy patients compared with healthy. The level of MDA was a significant increase meanwhile GSH and vitamin E there was a significant decrease, and vitamin C was insignificant changed. All Lipids profile were a significant increased except high density lipoprotein was a significant decrease in epilepsy patients compared to healthy. The correlation of lipoxygenase appears clear negative with uric acid, malondialdehyde, vitamin E in epilepsy patients and positive correlate in healthy. No effect of sex except for lipoxygenase, uric acid, GSH, and albumin in females compared with males. while MDA increased significantly in male compared femal. Also, no effect found of age on all the measured variables. This study indicates a significant increase of LOX activity in epilepsy patients compared healthy, and a clear negative relationship with uric acid, MDA and vitamin E.