Differences in the Receptor Binding Profile of Lofexidine Compared to Clonidine
Open Access
- 1 January 2019
- journal article
- research article
- Published by Scientific Research Publishing, Inc. in Pharmacology & Pharmacy
- Vol. 10 (01), 1-10
- https://doi.org/10.4236/pp.2019.101001
Abstract
Lucemyra® (lofexidine hydrochloride) has recently been approved by the US FDA for the mitigation of withdrawal symptoms to facilitate abrupt discontinuation of opioids in adults. Lofexidine is an alpha-2 adrenoceptor agonist. However, the clinical attributes of lofexidine differ in advantageous ways from the classical alpha-2 adrenoceptor agonist clonidine. In the present study, we measured the receptor binding profile of lofexidine and clonidine in an effort to gain an insight into the clinical difference(s).Keywords
This publication has 46 references indexed in Scilit:
- The locus coeruleus: A key nucleus where stress and opioids intersect to mediate vulnerability to opiate abuseBrain Research, 2010
- Why don’t out-of-treatment individuals enter methadone treatment programmes?International Journal of Drug Policy, 2010
- 5‐HT1A receptors are involved in the effects of xaliproden on G‐protein activation, neurotransmitter release and nociceptionBritish Journal of Pharmacology, 2009
- Tethered Yohimbine Analogs as Selective Human α2C-Adrenergic Receptor LigandsThe Journal of pharmacology and experimental therapeutics, 2006
- Are detoxification programmes effective?The Lancet, 1996
- Hill coefficients and the logistic equationTrends in Pharmacological Sciences, 1989
- Two stereoisomeric imidazoline derivatives. Synthesis, optical, and .alpha.2-adrenoceptor activitiesJournal of Medicinal Chemistry, 1986
- LOFEXIDINE, A CLONIDINE ANALOGUE EFFECTIVE IN OPIATE WITHDRAWALThe Lancet, 1981
- CLONIDINE BLOCKS ACUTE OPIATE-WITHDRAWAL SYMPTOMSThe Lancet, 1978
- Blocking of morphine based reinforcement by alpha-methyltyrosineLife Sciences, 1973