D1/5 dopamine receptors are necessary for learning a novel context
Open Access
- 16 May 2022
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Learning & Memory
- Vol. 29 (6), 142-145
- https://doi.org/10.1101/lm.053555.121
Abstract
Dopamine participates in encoding memories and could either encode rewarding/aversive value of unconditioned stimuli or act as a novelty signal triggering contextual learning. Here we show that intraperitoneal injection of the dopamine D1/5R antagonist SCH23390 impairs contextual fear conditioning and tone-shock association, while intrahippocampal injection only impairs contextual fear conditioning. By using the context pre-exposure facilitation effect test, we show that SCH23390 is able to block the encoding of the context during the pre-exposure phase. Thus, we provide additional evidence that dopamine is involved in encoding conjunctive representations of new contexts.Keywords
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