This study aims to determine the differences in knowledge of basic scientific work skills in students in the classroom. This research uses the Quasi Experiment method with The Non Equivalent, Pretest-Postest Design research design. The research sample consisted of 30 PGMI IAIN Palu students. The sampling technique used is Simple Random Sampling. Data collection techniques are using observation sheets. Data analysis techniques using the Normality test, Homogeneity test, and t test using the IBM SPSS Statistics 22 and Microsoft Excel programs. The results showed the significance value of Sig (2-Tailed) was 0.00