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Systematic nutrition management for locally advanced nasopharyngeal carcinoma patients undergoing radiotherapy.

Jian-Feng Huang, Ren-Juan Sun, Wen-Jun Jiang, Ping Wu, Li Zhang, Mei-Qin Xu, Le-Yuan Zhou, Qing-Feng Pang, Ya-Xian Wu, Bo Yang, Fu-Zheng Zhang
Published: 10 October 2019
OncoTargets and Therapy , Volume 12, pp 8379-8386; doi:10.2147/OTT.S213789

Abstract: To evaluate the impact of systematic nutrition management (SNM) on nutritional status, treatment-related toxicity, quality of life (QoL), response rates, and survival in patients with locally advanced nasopharyngeal carcinoma (LA-NPC) treated by radiotherapy (RT). In this retrospective study, 56 patients with LA-NPC were selected as nutrition management group (NG) for SNM during RT till 1 month later. Another 56 patients with LA-NPC receiving RT without SNM as control group (CG) were identified from the hospital database and matched pairs with NG patients according to age, gender, stage, and body mass index (BMI) prior to RT. At 1 month after RT, the percentage of malnourished patients with BMI 0.05) for the 2-year progression-free survival and overall survival (84.2% versus 79.5% and 94.7% versus 92.3%, respectively.). SNM for LA-NPC patients treated by RT resulted in better nutritional status, reduced treatment-related toxicity and improved QoL.
Keywords: nutrition management / radiotherapy / nasopharyngeal carcinoma / clinical outcome

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