Factors affecting in-hospital mortality of non-tuberculous mycobacterial pulmonary disease
Open Access
- 20 July 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Infectious Diseases
- Vol. 21 (1), 1-8
- https://doi.org/10.1186/s12879-021-06395-y
Abstract
The incidence and prevalence of non-tuberculous mycobacterial pulmonary disease (NTM-PD) are reportedly increasing in many parts of the world. However, there are few published data on NTM-PD-related death. Using data from a national inpatient database in Japan, we aimed in this study to identify the characteristics of patients with NTM-PD and clinical deterioration and to identify risk factors for in-hospital mortality. We examined data from the Diagnosis Procedure Combination (DPC) database in Japan from July 2010 to March 2014. We extracted data for HIV-negative NTM-PD patients who required unscheduled hospitalization. We evaluated these patients’ characteristics and performed multivariable logistic regression analysis to identify risk factors for all-cause in-hospital mortality. A total of 16,192 patients (median age: 78 years; women: 61.2%) were identified. The median body mass index (BMI) was 17.5 kg/m2 (IQR 15.4–20.0). All cause In-hospital death occurred in 3166 patients (19.6%). The median BMI of the patients who had died was 16.0 kg/m2 (IQR 14.2–18.4). Multivariable analysis revealed that increased mortality was associated with male sex, lower BMI, lower activities of daily living scores on the Barthel index, hemoptysis, and comorbidities, including pulmonary infection other than NTM, interstitial lung disease, pneumothorax, and malignant disease. We found associations between being underweight and having several comorbidities and increased in-hospital mortality in patients with NTM-PD. Preventing weight loss and management of comorbidities may have a crucial role in improving this disease’s prognosis.This publication has 28 references indexed in Scilit:
- Pulmonary Nontuberculous Mycobacterial Disease, Ontario, Canada, 1998–2010Emerging Infectious Diseases, 2013
- Patients with Nontuberculous Mycobacterial Lung Disease Exhibit Unique Body and Immune PhenotypesAmerican Journal of Respiratory and Critical Care Medicine, 2013
- Clinical Significance of the Differentiation Between Mycobacterium avium and Mycobacterium intracellulare in M avium Complex Lung DiseaseSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 2012
- Prevalence of Nontuberculous Mycobacterial Lung Disease in U.S. Medicare BeneficiariesAmerican Journal of Respiratory and Critical Care Medicine, 2012
- Prognostic Factors of 634 HIV-Negative Patients with Mycobacterium avium Complex Lung DiseaseAmerican Journal of Respiratory and Critical Care Medicine, 2012
- Nontuberculous Pulmonary Mycobacteriosis in DenmarkAmerican Journal of Respiratory and Critical Care Medicine, 2010
- Elevated Serum Adiponectin Level in Patients with Mycobacterium avium-intracellulare Complex Pulmonary DiseaseRespiration, 2009
- Cachexia: A new definitionClinical Nutrition, 2008
- Pulmonary Nontuberculous Mycobacterial DiseaseAmerican Journal of Respiratory and Critical Care Medicine, 2008
- An Official ATS/IDSA Statement: Diagnosis, Treatment, and Prevention of Nontuberculous Mycobacterial DiseasesAmerican Journal of Respiratory and Critical Care Medicine, 2007