Synthesis of iron oxide nanoparticles, characterization, uses as nanozyme and future prospects
- 1 December 2022
- journal article
- research article
- Published by Thomas Telford Ltd. in Bioinspired, Biomimetic and Nanobiomaterials
- Vol. 11 (4), 156-167
- https://doi.org/10.1680/jbibn.21.00068
Abstract
Iron oxide nanoparticles (NPs) have recently attracted wider attention because of their unique properties, such as superparamagnetism, larger surface area, surface-to-volume ratio, and simple manufacturing process. Several chemical, physical, and biological techniques have been employed to synthesize NPs with admissible surface chemistry. This paper summarises the approaches for producing iron oxide NPs, shape, and size management, and inviting properties in bioengineering, pharmaceutical, and modern applications. Iron oxides have significant potential in biology, climate change, and horticulture, among other fields. Surface coatings with organic or inorganic particles are one of a kind. The surface coatings of the IONPs are critical to their performance because they prevent nanoparticle aggregation, reduce the risk of immunogenicity, and limit nonspecific cellular uptake. Chitosan is a biodegradable polymer that is applied to iron oxide nanoparticles to coat them. Chitosan subordinates like O-HTCC (an ammonium-quaternary CS subsidiary) have a long-lasting positive charge that allows them to work in different pH ranges allowing their interactions with cell layers at physiological pH. By reacting epoxy propyl trimethyl ammonium chloride (ETA) with chitosan (CS), the hydro-solvent N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride (HTCC) is formed. For hyperthermic treatment of patients, NPs can also be coordinated to an organ, tissue, or tumor via an external attractive field. Given the increasing interest in iron NPs, the purpose of this review is to present data from iron oxide nanoparticles specially chitosan-capped iron NPs for different biomedical fields.This publication has 100 references indexed in Scilit:
- Superparamagnetic Iron Oxide Nanoparticles with Variable Size and an Iron Oxidation State as Prospective Imaging AgentsLangmuir, 2012
- Crystallographically-based analysis of the NMR spectra of maghemiteJournal of Magnetism and Magnetic Materials, 2012
- Tracer design for magnetic particle imaging (invited)Journal of Applied Physics, 2012
- Crucial Ignored Parameters on Nanotoxicology: The Importance of Toxicity Assay Modifications and “Cell Vision”PLOS ONE, 2012
- Magnetic nanomaterials for hyperthermia-based therapy and controlled drug deliveryAdvanced Drug Delivery Reviews, 2011
- A pretargeted nanoparticle system for tumor cell labelingMolecular BioSystems, 2010
- Application of Magnetic Nanoparticles in Pharmaceutical SciencesPharmaceutical Research, 2010
- Multifunctional magnetic nanoparticles for targeted deliveryNanomedicine: Nanotechnology, Biology and Medicine, 2010
- Magnetic nanoparticles: synthesis, functionalization, and applications in bioimaging and magnetic energy storageChemical Society Reviews, 2009
- The Importance of the CTAB Surfactant on the Colloidal Seed-Mediated Synthesis of Gold NanorodsLangmuir, 2008