35 years in plant lectin research: a journey from basic science to applications in agriculture and medicine
- 24 August 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Glycoconjugate Journal
- Vol. 39 (1), 83-97
- https://doi.org/10.1007/s10719-021-10015-x
Abstract
Plants contain an extended group of lectins differing from each other in their molecular structures, biochemical properties and carbohydrate-binding specificities. The heterogeneous group of plant lectins can be classified in several families based on the primary structure of the lectin domain. All proteins composed of one or more lectin domains, or having a domain architecture including one or more lectin domains in combination with other protein domains can be defined as lectins. Plant lectins reside in different cell compartments, and depending on their location will encounter a large variety carbohydrate structures, allowing them to be involved in multiple biological functions. Over the years lectins have been studied intensively for their carbohydrate-binding properties and biological activities, which also resulted in diverse applications. The present overview on plant lectins especially focuses on the structural and functional characteristics of plant lectins and their applications for crop improvement, glycobiology and biomedical research.Keywords
Funding Information
- Universiteit Gent
- KU Leuven
- Francqui Research Foundation
- FWO
This publication has 149 references indexed in Scilit:
- Plant lectins as defense proteins against phytophagous insectsPhytochemistry, 2011
- Targeting of T/Tn Antigens with a Plant Lectin to Kill Human Leukemia Cells by PhotochemotherapyPLOS ONE, 2011
- Comparative Study of the Phototoxicity of Long-Wavelength Photosensitizers Targeted by the MornigaG LectinBioconjugate Chemistry, 2011
- Interaction of the Tobacco Lectin with Histone ProteinsPlant Physiology, 2011
- Nicotiana tabacum agglutinin is active against Lepidopteran pest insectsJournal of Experimental Botany, 2009
- Plant Lectins: A Composite of Several Distinct Families of Structurally and Evolutionary Related Proteins with Diverse Biological RolesCritical Reviews in Plant Sciences, 1998
- Legume lectin structureBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1998
- Molecular cloning of the mitogenic mannose/maltose‐specific rhizome lectin from Calystegia sepiumFEBS Letters, 1996
- The Mannose-specific Bulb Lectin fromGalanthus nivalis(Snowdrop) Binds Mono- and Dimannosides at Distinct Sites. Structure Analysis of Refined Complexes at 2.3 Å and 3.0 Å ResolutionJournal of Molecular Biology, 1996
- Isolation and characterization of a lectin with exclusive specificity towards mannose from snowdrop (Galanthus nivalis) bulbsFEBS Letters, 1987