PECULIARITIES OF MORPHOGENESIS OF CHANGES IN THE PERIODONTIUM AT EXPERIMENTAL ACTION OF OPIOID DURING TWO WEEKS AND ITS SUBSEQUENT FOUR WEEKS CANCELLATION AND CORRECTION

Abstract

The aim of the study was to examine the periodontal tissues of white rats under two weeks of opioid exposure, after its abolition and drug correction for four weeks at the optical level. After two weeks of experimental action of the opioid analgesic and its subsequent four-week withdrawal, pronounced irreversible changes in the structural components of the periodontium of animals were not detected, however, and their complete recovery was not observed. The proposed drug correction with pentoxifylline and ceftriaxone with opioid withdrawal after two weeks of its administration, led to the restoration of microcirculation and trophic tissues of periodontal tissues of rats, their morphological organization was approaching normal.