Loneliness and the Social Brain: How Perceived Social Isolation Impairs Human Interactions
Open Access
- 20 September 2021
- journal article
- research article
- Published by Wiley in Advanced Science
- Vol. 8 (21), 2102076
- https://doi.org/10.1002/advs.202102076
Abstract
Loneliness is a painful condition associated with increased risk for premature mortality. The formation of new, positive social relationships can alleviate feelings of loneliness, but requires rapid trustworthiness decisions during initial encounters and it is still unclear how loneliness hinders interpersonal trust. Here, a multimodal approach including behavioral, psychophysiological, hormonal, and neuroimaging measurements is used to probe a trust-based mechanism underlying impaired social interactions in loneliness. Pre-stratified healthy individuals with high loneliness scores (n = 42 out of a screened sample of 3678 adults) show reduced oxytocinergic and affective responsiveness to a positive conversation, report less interpersonal trust, and prefer larger social distances compared to controls (n = 40). Moreover, lonely individuals are rated as less trustworthy compared to controls and identified by the blinded confederate better than chance. During initial trust decisions, lonely individuals exhibit attenuated limbic and striatal activation and blunted functional connectivity between the anterior insula and occipitoparietal regions, which correlates with the diminished affective responsiveness to the positive social interaction. This neural response pattern is not mediated by loneliness-associated psychological symptoms. Thus, the results indicate compromised integration of trust-related information as a shared neurobiological component in loneliness, yielding a reciprocally reinforced trust bias in social dyads.This publication has 55 references indexed in Scilit:
- Glucose Metabolism in the Insula and Cingulate Is Affected by Systemic Inflammation in HumansJournal of Nuclear Medicine, 2012
- The human amygdala is necessary for developing and expressing normal interpersonal trustNeuropsychologia, 2011
- Self-Control in Decision-Making Involves Modulation of the vmPFC Valuation SystemScience, 2009
- In the Eye of the Beholder: Individual Differences in Perceived Social Isolation Predict Regional Brain Activation to Social StimuliJournal of Cognitive Neuroscience, 2009
- The Social Brain: Neural Basis of Social KnowledgeAnnual Review of Psychology, 2009
- Oxytocin Shapes the Neural Circuitry of Trust and Trust Adaptation in HumansNeuron, 2008
- Social cognition and the brain: A meta‐analysisHuman Brain Mapping, 2008
- Can cognitive processes be inferred from neuroimaging data?Trends in Cognitive Sciences, 2006
- Oxytocin increases trust in humansNature, 2005
- Bayes FactorsJournal of the American Statistical Association, 1995