Erratum for the Research Article “The genetic architecture of the human cerebral cortex,” by K. L. Grasby et al .

Abstract

In May 2020, the authors of the Research Article “The genetic architecture of the human cerebral cortex” found a formatting error in one of the phenotype files that was used to perform genome-wide association (GWAS) analyses within the UK Biobank cohort. The authors immediately informed Science and requested that an Erratum be published and the paper be corrected. At this time, the authors also updated the publicly available GWAS summary statistics for this work and contacted those who had downloaded the summary statistics and advised them to download the corrected summary statistics. The error affected only the regional cortical thickness imaging phenotypes in this cohort. The error occurred when the file was sorted by participant ID and resulted in the randomization of IDs within this file. This meant that in the GWAS meta-analyses for the regional cortical thickness imaging phenotypes, the GWAS results from this cohort contributed random noise rather than true signal. None of the other 59 cohorts contributing to the meta-analysis were affected; the average cortical thickness was not affected by this error, nor were the total or regional cortical surface area phenotypes.