CRISPR/Cas9-mediated knockout of Rag-2 causes systemic lymphopenia with hypoplastic lymphoid organs in FVB mice
Open Access
- 1 January 2018
- journal article
- Published by Springer Science and Business Media LLC in Laboratory Animal Research
- Vol. 34 (4), 166-175
- https://doi.org/10.5625/lar.2018.34.4.166
Abstract
Kim JI, et al. Lab Anim Res. 2018 Dec;34(4):166-175. https://doi.org/10.5625/lar.2018.34.4.166Keywords
Funding Information
- Ministry of Food and Drug Safety (14182MFDS978)
This publication has 21 references indexed in Scilit:
- Disruption of the RAG2 zinc finger motif impairs protein stability and causes immunodeficiencyEuropean Journal of Immunology, 2016
- NOD/SCID/γcnull mouse: an excellent recipient mouse model for engraftment of human cellsBlood, 2002
- V(D)J Recombination: RAG Proteins, Repair Factors, and RegulationAnnual Review of Biochemistry, 2002
- Omenn Syndrome: A Disorder of Rag1 and Rag2 GenesJournal of Clinical Immunology, 1999
- Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two stepsCell, 1995
- Functional analysis of the antigen binding site on the T cell receptor alpha chain.The Journal of Experimental Medicine, 1992
- RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangementCell, 1992
- RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J RecombinationScience, 1990
- The V(D)J recombination activating gene, RAG-1Cell, 1989
- Somatic generation of antibody diversityNature, 1983