Different protein unfolding mechanisms (i.e. pressure, temperature, chemical, and force) produces an ensemble of conformations that is distinct from the others. A logical question is, should this matter? While this question does not yet have a complete answer, there are tantalizing indications that it does. This study, together with {1}, found that temperature jump and pressure jump of the Fip35 fragment of a WW domain yielded very similar kinetics, as does temperature jump and rapid dilution of denaturant of a different WW domain, Pin1. This Recommendation is of an article referenced in an F1000 Faculty Review also written by Lisa J Lapidus.