MRI and CT coronary angiography in survivors of COVID-19
Open Access
- 6 October 2021
- Vol. 108 (1), 46-53
- https://doi.org/10.1136/heartjnl-2021-319926
Abstract
Objectives To determine the contribution of comorbidities on the reported widespread myocardial abnormalities in patients with recent COVID-19. Methods In a prospective two-centre observational study, patients hospitalised with confirmed COVID-19 underwent gadolinium and manganese-enhanced MRI and CT coronary angiography (CTCA). They were compared with healthy and comorbidity-matched volunteers after blinded analysis. Results In 52 patients (median age: 54 (IQR 51–57) years, 39 males) who recovered from COVID-19, one-third (n=15, 29%) were admitted to intensive care and a fifth (n=11, 21%) were ventilated. Twenty-three patients underwent CTCA, with one-third having underlying coronary artery disease (n=8, 35%). Compared with younger healthy volunteers (n=10), patients demonstrated reduced left (ejection fraction (EF): 57.4±11.1 (95% CI 54.0 to 60.1) versus 66.3±5 (95 CI 62.4 to 69.8)%; p=0.02) and right (EF: 51.7±9.1 (95% CI 53.9 to 60.1) vs 60.5±4.9 (95% CI 57.1 to 63.2)%; p≤0.0001) ventricular systolic function with elevated native T1 values (1225±46 (95% CI 1205 to 1240) vs 1197±30 (95% CI 1178 to 1216) ms;p=0.04) and extracellular volume fraction (ECV) (31±4 (95% CI 29.6 to 32.1) vs 24±3 (95% CI 22.4 to 26.4)%; pConclusions Patients demonstrate right but not left ventricular dysfunction. Previous reports of left ventricular myocardial abnormalities following COVID-19 may reflect pre-existing comorbidities. Trial registration number NCT04625075.Keywords
Funding Information
- Medical Research Council (MR/T029153/1).)
- Public Health Research Programme (RP-2017-08-ST2-007)
- British Heart Foundation (CH/09/002, CS/17/1/32445, FS/14/78/31020, RE/18/5/34216, RG/16/10/32375)
- Wellcome Trust (WT103782AIA)
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