A framework for application of quantitative property-property relationships (QPPRs) in physiologically based pharmacokinetic (PBPK) models for high-throughput prediction of internal dose of inhaled organic chemicals
- 8 October 2018
- journal article
- research article
- Published by Elsevier BV in Chemosphere
- Vol. 215, 634-646
- https://doi.org/10.1016/j.chemosphere.2018.10.041
Abstract
No abstract availableKeywords
Funding Information
- Luonnontieteiden ja Tekniikan Tutkimuksen Toimikunta
This publication has 43 references indexed in Scilit:
- Advancing Prediction of Tissue Distribution and Volume of Distribution of Highly Lipophilic Compounds from a Simplified Tissue-Composition-Based Model as a Mechanistic Animal Alternative MethodJournal of Pharmaceutical Sciences, 2012
- Predicting blood:air partition coefficients using basic physicochemical propertiesRegulatory Toxicology and Pharmacology, 2012
- Quantitative Property-Property Relationship for Screening-Level Prediction of Intrinsic Clearance of Volatile Organic Chemicals in Rats and Its Integration within PBPK Models to Predict Inhalation Pharmacokinetics in HumansJournal of Toxicology, 2012
- QSARs for PBPK modelling of environmental contaminantsSAR and QSAR in Environmental Research, 2011
- PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicalsToxicology, 2010
- A unified algorithm for predicting partition coefficients for PBPK modeling of drugs and environmental chemicalsToxicology and Applied Pharmacology, 2010
- Evaluation of a Generic Physiologically Based Pharmacokinetic Model for Lineshape AnalysisClinical Pharmacokinetics, 2008
- APPLICATION OF A GENERIC PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL TO THE ESTIMATION OF XENOBIOTIC LEVELS IN HUMAN PLASMADrug Metabolism and Disposition, 2005
- Air to Blood Distribution of Volatile Organic Compounds: A Linear Free Energy AnalysisChemical Research in Toxicology, 2005
- Physiological Parameter Values for Physiologically Based Pharmacokinetic ModelsToxicology and Industrial Health, 1997