Antidepressant-like activity of the dipeptide mimetic of brain-derived neurotrophic factor GSB-106 in Porsolt test after intraperitoneal sub-chronically and chronically treatment in mice
Open Access
- 28 April 2020
- journal article
- Published by Publishing House OKI in Pharmacokinetics and Pharmacodynamics
- No. 4,p. 24-27
- https://doi.org/10.37489/2587-7836-2019-4-24-27
Abstract
The present work was to study the GSB-106 effect on the immobility behavior of mice Balb/c in the Porsolt test. GSB-106 was administered sub-chronically and chronically intraperitoneal in dose 1 mg/kg. GSB-106 administration significantly decreased immobility time in mice by 1.2 times after 4 days, by 1.3 times after 14 days and 1.2 times after 21 days’ injections. Thus, the dependence of the GSB-106 effect-time administration in the Porsolt test was not established.Keywords
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