Antimicrobials from Medicinal Plants: An Emergent Strategy to Control Oral Biofilms
Open Access
- 28 April 2021
- journal article
- review article
- Published by MDPI AG in Applied Sciences
- Vol. 11 (9), 4020
- https://doi.org/10.3390/app11094020
Abstract
Oral microbial biofilms, directly related to oral diseases, particularly caries and periodontitis, exhibit virulence factors that include acidification of the oral microenvironment and the formation of biofilm enriched with exopolysaccharides, characteristics and common mechanisms that, ultimately, justify the increase in antibiotics resistance. In this line, the search for natural products, mainly obtained through plants, and derived compounds with bioactive potential, endorse unique biological properties in the prevention of colonization, adhesion, and growth of oral bacteria. The present review aims to provide a critical and comprehensive view of the in vitro antibiofilm activity of various medicinal plants, revealing numerous species with antimicrobial properties, among which, twenty-four with biofilm inhibition/reduction percentages greater than 95%. In particular, the essential oils of Cymbopogon citratus (DC.) Stapf and Lippia alba (Mill.) seem to be the most promising in fighting microbial biofilm in Streptococcus mutans, given their high capacity to reduce biofilm at low concentrations.Keywords
This publication has 216 references indexed in Scilit:
- Antimicrobial Activity of Essential Oils againstStreptococcus mutansand their Antiproliferative EffectsEvidence-Based Complementary and Alternative Medicine, 2012
- Fusobacterium nucleatum infection is prevalent in human colorectal carcinomaGenome Research, 2011
- Biology of Streptococcus mutans-Derived Glucosyltransferases: Role in Extracellular Matrix Formation of Cariogenic BiofilmsCaries Research, 2011
- Traditional Medicinal Plant Extracts and Natural Products with Activity against Oral Bacteria: Potential Application in the Prevention and Treatment of Oral DiseasesEvidence-Based Complementary and Alternative Medicine, 2011
- The Human Oral MicrobiomeJournal of Bacteriology, 2010
- Biofilm Dispersal: Mechanisms, Clinical Implications, and Potential Therapeutic UsesJournal of Dental Research, 2010
- TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjectsJournal of Neuroimmunology, 2009
- Localization of P. gingivalis in Preterm Delivery PlacentaJournal of Dental Research, 2009
- Three flavonoids targeting the β‐hydroxyacyl‐acyl carrier protein dehydratase from Helicobacter pylori: Crystal structure characterization with enzymatic inhibition assayProtein Science, 2008
- Detection of Cariogenic Streptococcus mutans in Extirpated Heart Valve and Atheromatous Plaque SpecimensJournal of Clinical Microbiology, 2006