The Factor V G1691A, Factor V H1299R, prothrombin G20210A polymorphisms in children with family history of premature coronary artery disease
- 1 November 2009
- journal article
- pathophysiology and-natural-history
- Published by Ovid Technologies (Wolters Kluwer Health) in Coronary Artery Disease
- Vol. 20 (7), 435-439
- https://doi.org/10.1097/mca.0b013e32832bdb8c
Abstract
Atherosclerosis, the major cause of coronary artery disease (CAD), has a very long asymptomatic development phase, which begins in childhood. In this study, we describe the Factor V G1691A, Factor V H1299R and prothrombin G20210A gene polymorphisms in children with a family history of premature CAD. Evidence of these polymorphisms in these children may predict the probability of having atherosclerosis in the future. Our study included a total of 140 children, 72 males and 68 females between the ages of 4.9 and 15.7 years. Among these children, 73 had a parental history of premature CAD and the remaining 67 belonged to our control group. The participants were screened for the mutations Factor V G1691A, Factor V H1299R and prothrombin G20210A by polymerase chain reaction amplified DNA products with specific oligonucleotide probes. Our results suggested that frequencies of the mutated allele of Factor V G1691A and prothrombin G20210A are higher in children with a parental history of premature CAD. In conclusion, Factor V G1691A and prothrombin G20210A polymorphisms which were detected in higher frequencies in children with a parental history of premature CAD may indicate a risk for developing atherosclerosis and might be useful in screening for CAD in children; however, large population-based research is necessary to investigate further genetic risk assessment for CAD.Keywords
This publication has 16 references indexed in Scilit:
- Factor VLeiden and Prothrombin G20210A Gene Polymorphisms in Patients with Coronary Artery DiseaseYonsei Medical Journal, 2008
- Early atherosclerosis in childhood: Diagnostic approaches and therapeutic strategiesInternational Journal of Cardiology, 2006
- Analysis of some clinical and laboratory aspects of adolescent patients with thrombosisBlood Coagulation & Fibrinolysis, 2004
- Clinical application of genetic risk assessment strategies for coronary artery disease: genotypes, phenotypes, and family historyPrimary Care: Clinics in Office Practice, 2004
- Factor V Leiden: The Copenhagen City Heart Study and 2 meta-analysesBlood, 2002
- Genetic predisposition to coronary artery diseaseCurrent Opinion in Cardiology, 2001
- Prevalence of factor v leiden and prothrombin variant g20210a in patients age <50 years with no significant stenoses at angiography three to four weeks after myocardial infarctionJournal of Invasive Cardiology, 2000
- Combinations of 4 mutations (FV R506Q, FV H1299R, FV Y1702C, PT 20210G/A) affecting the prothrombinase complex in a thrombophilic familyBlood, 2000
- Is Acquired Activated Protein C Resistance a Cardiovascular Risk?Journal of the American College of Cardiology, 2000
- Resistance to activated protein C and FV leiden mutation in patients with a history of acute myocardial infarction or primary hypertension.American Journal of Hypertension, 2000