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Factors Associated With Elevated N-Terminal Pro B-Type Natriuretic Peptide Concentrations at the Convalescent Stage and 1-Year Outcomes in Patients With Heart Failure With Preserved Ejection Fraction

Bolrathanak Oeun, Daisaku Nakatani, Shungo Hikoso, Takayuki Kojima, Tomoharu Dohi, Tetsuhisa Kitamura, Katsuki Okada, Akihiro Sunaga, Hirota Kida, Takahisa Yamada, Masaaki Uematsu, Yoshio Yasumura, Yoshiharu Higuchi, Toshiaki Mano, Yoshiyuki Nagai, Hisakazu Fuji, Hiroya Mizuno, Yasushi Sakata, for the Osaka CardioVascular Conference (OCVC) Heart Failure Investigators
Published: 7 August 2020
Circulation Reports , Volume 2, pp 400-408; doi:10.1253/

Abstract: Background:Little is known about factors associated with elevated N-terminal pro B-type natriuretic peptide (NT-proBNP) at the convalescent stage and their effects on 1-year outcomes in patients with heart failure with preserved ejection fraction (HFpEF). Methods and Results:This study included 469 patients with HFpEF. Elevated NT-proBNP was defined as the highest quartile. The first 3 quartiles (Q1–Q3) were combined together for comparison with the fourth quartile (Q4). Median NT-proBNP concentrations in Q1–Q3 and Q4 were 669 and 3,504 pg/mL, respectively. Multivariate logistic regression analysis revealed that low albumin (odds ratio [OR] 2.44; 95% confidence interval [CI] 1.35–4.39; P=0.003), low estimated glomerular filtration rate (OR 5.83; 95% CI 3.46–9.83; P
Keywords: Protein / Heart / HFpEF / ProBNP / Quartile / Convalescent / Associated with Elevated / Elevated Nt

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