Antibiotic-Resistant Uropathogenic Escherichia coli Isolated from Children with Congenital Abnormalities of the Kidneys and Urinary Tract
- 21 November 2020
- journal article
- Published by Publishing House OKI in Antibiotics and Chemotherapy
- Vol. 65 (7-8), 23-26
- https://doi.org/10.37489/0235-2990-2020-65-7-8-23-26
Abstract
Uropathogenic Escherichia coli (UPEC) is a serious health problem worldwide. UPEC's multiple drug resistance combined with virulence factors is a cause of serious concern. In childhood, urinary tract infections are of particular importance, since they can occur against the background of long-term unrecognized congenital anomalies of the kidneys and urinary tract. Of the 106 UPEC clinical isolates, 63.2% of cultures were isolated from girls' urine samples and 36.8% from boys' urine samples, which corresponds to a 1.7: 1 ratio. The antibiotic resistance of the isolated UPEC cultures was assessed in relation to 12 antimicrobial drugs. Among the tested cultures, 49% were multidrug-resistant and 20.75% were found to be resistant to imipenem. Phenotypic analysis of antibiotic susceptibility spectrum of uropathogenic E.coli (n=106) indicates a high percentage of occurrence of multi-resistant UPEC strains (49%) and imipenem-resistant UPEC strains (20.75%) among children of all age groups.Keywords
This publication has 9 references indexed in Scilit:
- Antibiotic resistance, virulence factors and genotyping of Uropathogenic Escherichia coli strainsAntimicrobial Resistance & Infection Control, 2018
- Phylogenetic group distributions, virulence factors and antimicrobial resistance properties of uropathogenic Escherichia coli strains isolated from patients with urinary tract infections in South KoreaLetters in Applied Microbiology, 2015
- Virulence factors of uropathogenic Escherichia coli of urinary tract infections and asymptomatic bacteriuria in childrenJournal of Microbiology, Immunology and Infection, 2014
- Distribution of uropathogenic virulence genes in Escherichia coli isolated from patients with urinary tract infectionInternational Journal of Infectious Diseases, 2013
- Uncomplicated Urinary Tract InfectionThe New England Journal of Medicine, 2012
- Host–pathogen interactions in urinary tract infectionNature Reviews Urology, 2010
- Complicated urinary tract infectionsCurrent Infectious Disease Reports, 2008
- Epidemiological Correlates of Virulence Genotype and Phylogenetic Background amongEscherichia coliBlood Isolates from Adults with Diverse‐Source BacteremiaThe Journal of Infectious Diseases, 2002
- Urinary Tract Infections: Disease Panorama and ChallengesThe Journal of Infectious Diseases, 2001