Anti-inflammatory Activity of Pharmaceutical Gel of Ethanolic Extract from Marine Sponge Xestospongia Sp
Open Access
- 4 May 2019
- journal article
- Published by Universitas Muhammadiyah Palangkaraya in Borneo Journal of Pharmacy
- Vol. 2 (1), 1-9
- https://doi.org/10.33084/bjop.v2i1.694
Abstract
The aim of this study was to determine the characteristics of the gel formula based on it’s organoleptic properties, pH, viscosity, dispersion and homogenity by stability test carried out using the cycling test method and to determine the anti-inflammatory activity of the Xestospongia Sp. in male white mice (Mus musculus) by creating an artificial edema on the mice left foot induced by 1% λ-carrageenan. The gel formula from the ethanol extract of Xestospongia Sp. sponge was physically stable in terms of its organoleptic observation, homogenity, pH and viscosity test. However, the results that were obtained after dispersion test did not fulfill the requirements. In this study, the gel formula of the ethanol extract of Xestospongia Sp. sponge was administered on the mice left foot by using the variations in extract concentration of 0.02%, 0.03%, and 0.04%, and the gel without extract as a negative control and Galtaren®gel (1% Diclofenac Sodium) as a positive control. The evaluated data were in the form of mice leg edema volume measured based on its percent of inflammation and percent of inflammatory inhibition and observed for 360 minutes. The data were analyzed by using the Kruskal-Wallis test followed by the Mann-Whitney test with a confidence level of 95%. The results of this study showed that the gel formula of ethanol extract of Xestospongia Sp. sponge has an anti-inflammatory effect on each concentration and the formula that has a large anti-inflammatory effect was obtained at extract concentration of 0.04%.Keywords
Funding Information
- Kementerian Riset Teknologi Dan Pendidikan Tinggi Republik Indonesia
This publication has 17 references indexed in Scilit:
- PREPARASI ETOSOM EKSTRAK ETANOL BIJI KOPI (Coffea arabica L.) MENGGUNAKAN VARIASI KONSENTRASI SOYA LESITIN DAN ETANOLMajalah Farmasi dan Farmakologi, 2019
- In vitro and In vivo Anti-inflammatory Activities of Coptosapelta flavescens Korth Root’s Methanol ExtractJournal of Applied Pharmaceutical Science, 2018
- EKSPLORASI SPONS INDONESIA: SEPUTAR KEPULAUAN SPERMONDEPublished by Center for Open Science ,2018
- Uji aktivitas gel ekstrak daun pohpohan (Pilea trinervia W.) terhadap penyembuhan luka bakar pada kelinci (Oryctolagus cuniculus)Kartika : Jurnal Ilmiah Farmasi, 2017
- Antiinflammatory Activity Test of Aqueous Extracts Herb of Ciplukan (Physalis angulata L.) in Caragenan Inducted Wistar Rat (Rattus norvegicus L.)Majalah Obat Tradisional, 2017
- Uji Toksisitas Akut Ekstrak Spons Laut (Callyspongia aerizusa) terhadap Larva Artemia salina Leach dengan Metode Brine Shrimp Lethality TestJurnal e-Biomedik, 2017
- Evaluation of the Anti-Inflammatory, Antioxidant and Immunomodulatory Effects of the Organic Extract of the Red Sea Marine Sponge Xestospongia testudinaria against Carrageenan Induced Rat Paw InflammationPLOS ONE, 2015
- Marine Sponge Derived Natural Products between 2001 and 2010: Trends and Opportunities for Discovery of BioactivesMarine Drugs, 2014
- Models of Inflammation: Carrageenan Air PouchCurrent Protocols in Pharmacology, 2012
- 1 Indonesia as an Archipelago: Managing Islands, Managing the SeasPublished by ISEAS - Yusof Ishak Institute ,2009