SUBCHRONIC TOXICITY OF MICROENCAPSULATED PROBIOTIC DRUG “ENZYMSPORINE WITH TRYPSIN” AND ITS APPLICATION IN PIG PRODUCTION

Abstract

The rationale for the study is explained by the fact that regular application of probiotic feeding supplements in pig breeding positively influences the growth and development of young stock, in particular, increases mean daily weight gain, normalizes the performance of the gastrointestinal tract and enforces the resistance of the organism. For this reason, a microencapsulated probiotic drug ―Enzymsporine withtrypsin‖ was developed in the facilities of Kursk State Agricultural Academy (Kursk, Russia). The authors studied the drug’s biological safety. The main method of the study of biological safety of the drug was the study of its subchronic toxicity that would allow for the production trials of this drug on agricultural animals. The article presents the experimental data obtained during the tests on Wistar rats.The tests on rats showed that new encapsulated probiotic drug ―Enzymsporine with trypsin‖ was safe in the doses that exceeded the recommended for the application in animal farming by 2 and 10 times. This provided perspectives for the application of this drug in animal production for the optimization of metabolism, an increase in the mass of animals, and the safety of meat products for humans.