Peroxiredoxins—The Underrated Actors during Virus-Induced Oxidative Stress
Open Access
- 18 June 2021
- journal article
- review article
- Published by MDPI AG in Antioxidants
- Vol. 10 (6), 977
- https://doi.org/10.3390/antiox10060977
Abstract
Enhanced production of reactive oxygen species (ROS) triggered by various stimuli, including viral infections, has attributed much attention in the past years. It has been shown that different viruses that cause acute or chronic diseases induce oxidative stress in infected cells and dysregulate antioxidant its antioxidant capacity. However, most studies focused on catalase and superoxide dismutases, whereas a family of peroxiredoxins (Prdx), the most effective peroxide scavengers, were given little or no attention. In the current review, we demonstrate that peroxiredoxins scavenge hydrogen and organic peroxides at their physiological concentrations at various cell compartments, unlike many other antioxidant enzymes, and discuss their recycling. We also provide data on the regulation of their expression by various transcription factors, as they can be compared with the imprint of viruses on transcriptional machinery. Next, we discuss the involvement of peroxiredoxins in transferring signals from ROS on specific proteins by promoting the oxidation of target cysteine groups, as well as briefly demonstrate evidence of nonenzymatic, chaperone, functions of Prdx. Finally, we give an account of the current state of research of peroxiredoxins for various viruses. These data clearly show that Prdx have not been given proper attention despite all the achievements in general redox biology.Funding Information
- Russian Science Foundation (19-74-10086 and 19-14-00197)
This publication has 169 references indexed in Scilit:
- Dynamic Regulation of Ero1α and Peroxiredoxin 4 Localization in the Secretory PathwayOnline Journal of Public Health Informatics, 2013
- A new type of protein chip to detect hepatocellular carcinoma-related autoimmune antibodies in the sera of hepatitis C virus-positive patientsProteome Science, 2013
- HCV and Oxidative Stress in the LiverViruses, 2013
- Moonlighting by Different Stressors: Crystal Structure of the Chaperone Species of a 2-Cys PeroxiredoxinStructure, 2012
- Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stressCell Death & Disease, 2011
- Glutathionylation of Peroxiredoxin I Induces Decamer to Dimers Dissociation with Concomitant Loss of Chaperone ActivityBiochemistry, 2011
- Both Thioredoxin 2 and Glutaredoxin 2 Contribute to the Reduction of the Mitochondrial 2-Cys Peroxiredoxin Prx3Online Journal of Public Health Informatics, 2010
- Proteomic analyses of monocytes obtained from Hispanic women with HIV‐associated dementia show depressed antioxidantsProteomics – Clinical Applications, 2010
- The Antioxidant Enzyme Prdx1 Controls Neuronal Differentiation by Thiol-Redox-Dependent Activation of GDE2Cell, 2009
- Transcriptional Regulation of the AP-1 and Nrf2 Target Gene SulfiredoxinMolecules and Cells, 2009