Health-Related Quality of Life in Patients with Biliary Atresia: A Systematic Review and Meta-Analysis
Open Access
- 16 June 2019
- journal article
- review article
- Published by Briefland in Iranian Journal of Pediatrics
- Vol. 29 (3)
- https://doi.org/10.5812/ijp.83559
Abstract
Objectives: In this systematic review and meta-analysis, for the first time, the existing evidence on health-related quality of life (HRQOL) was evaluated in patients with biliary atresia (BA) and compared with that of healthy population. Methods: A systematic search was done on PubMed, Scopus, Embase, Cochrane Library and Web of Science from 1990 up to April 2018 in order to identify all articles that assess the HRQOL in patients with BA. Meta-analysis was done using comprehensive meta-analysis and the standard difference of mean (SDM) was calculated. Results: A total of 188 publications were identified from the initial search. After removing duplicates and irrelevant studies, 32 articles remained for full-text evaluation. Out of this number, 22 articles were excluded due to non-relevance to the study scope leaving 10 studies for systematic review and three articles for meta-analysis. HRQOL was assessed using PedsQL4 in three studies, SF-36C in two studies and by assessing different parameters including social status, school, university, and/or sports performance in five studies. HRQOL in BA patients living with their own liver was significantly lower than that of the general population [SDM = -0.55 (95% CI: -0.69, -0.40)]. In the terms of PedsQL4 sub-scores, compared with healthy population, the levels of physical [SDM = -0.40 (95% CI: -0.55, -0.28)], social [SDM = -0.25 (95% CI: -0.40, -0.11)] and school functioning [SDM = -1.19 (95% CI: -2.35, 0.07)] were significantly lower in the group of biliary atresia. Keywords: Quality of Life; Extra Hepatic Biliary Atresia; PedsQL4Keywords
This publication has 27 references indexed in Scilit:
- Language and Motor Skills Are Impaired in Infants with Biliary Atresia Before TransplantationThe Journal of Pediatrics, 2010
- Insignificant seasonal and geographical variation in incidence of biliary atresia in Japan: a regional survey of over 20 yearsJournal of Pediatric Surgery, 2007
- Outcome in adulthood of biliary atresia: A study of 63 patients who survived for over 20 years with their native liverJournal of Hepatology, 2005
- Measuring inconsistency in meta-analysesBMJ, 2003
- Neonatal CholestasisSeminars in Pediatric Surgery, 2000
- Epidemiology of biliary atresia in France: a national study 1986–96Journal of Hepatology, 1999
- The Outcome of Surgery for Biliary Atresia and the Current Status of Long-Term Survivors.The Tohoku Journal of Experimental Medicine, 1997
- Conventional treatment of biliary atresia: Long-term resultsJournal of Pediatric Surgery, 1996
- Current status of 21 patients who have survived more than 20 years since undergoing surgery for biliary atresiaJournal of Pediatric Surgery, 1996
- Long-term follow-up after surgery for patients with biliary atresiaJournal of Pediatric Surgery, 1990