The role of dendritic cells in COVID-19 infection
Open Access
- 9 May 2023
- journal article
- research article
- Published by Taylor & Francis Ltd in Emerging Microbes & Infections
- Vol. 12 (1), 2195019
- https://doi.org/10.1080/22221751.2023.2195019
Abstract
The persistent pandemic of coronavirus disease in 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) currently poses a major infectious threat to public health around the world. COVID-19 is an infectious disease characterized by strong induction of inflammatory cytokines, progressive lung inflammation, and potential multiple organ dysfunction. SARS-CoV-2 infection is closely related to the innate immune system and adaptive immune system. Dendritic cells (DCs), as a "bridge" connecting innate immunity and adaptive immunity, play many important roles in viral diseases. In this review, we will pay special attention to the possible mechanism of dendritic cells in human viral transmission and clinical progression of diseases, as well as the reduction and dysfunction of DCs in severe SARS-CoV-2 infection, so as to understand the mechanism and immunological characteristics of SARS-CoV-2 infection.Keywords
Funding Information
- R&D Program of Guangzhou Laboratory (SRPG22-006)
- National Natural Science Foundation of China (31970839, 32100709)
- China Postdoctoral Science Foundation (2020M682419)
- HUST Academic Frontier Youth Team (2018QYTD10)
- Medjaden Academy & Research Foundation for Young Scientists (MJR20221009, MJR20221030)
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