Estimating the risk of incident SARS-CoV-2 infection among healthcare workers in quarantine hospitals: the Egyptian example
Preprint
- 11 August 2022
- preprint
- Published by Research Square Platform LLC
Abstract
In response to the COVID-19 epidemic, Egypt established a unique care model based on quarantine hospitals where only externally-referred confirmed COVID-19 patients were admitted, and healthcare workers resided continuously over 1- to 2-week working shifts. While the COVID-19 risk for HCWs has been widely reported in standard healthcare settings, it has not been evaluated yet in quarantine hospitals. Here, we relied on longitudinal data, including results of routine RT-PCR tests, collected within three quarantine hospitals located in Cairo and Fayoum, Egypt. Using a mathematical model accounting for the time-since-exposure variation in false-negative rates of RT-PCR tests, we computed the incidence rate of SARS-CoV-2 infection among HCWs. Our results thus unveil the proportion of infections remaining undiagnosed despite routine testing. We estimated that the risk for an HCW to be infected during a working shift lied within the range of risk levels previously documented in standard healthcare settings for two quarantine hospitals, whereas it was > 3-fold higher for the third hospital. This large variation suggests that HCWs from quarantine hospitals may face a high occupational risk of infection, but that, with sufficient infection control measures, this risk can be brought down to levels similar to those observed in standard healthcare settings.Keywords
This publication has 19 references indexed in Scilit:
- Universal COVID-19 screening of 4040 health care workers in a resource-limited setting: an Egyptian pilot model in a university with 12 public hospitals and medical centersInternational Journal of Epidemiology, 2020
- Variation in False-Negative Rate of Reverse Transcriptase Polymerase Chain Reaction–Based SARS-CoV-2 Tests by Time Since ExposureAnnals of Internal Medicine, 2020
- SARS-CoV-2 infection among healthcare workers of a gastroenterological service in a tertiary care facilityArab Journal of Gastroenterology, 2020
- Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workersThe Lancet, 2020
- COVID-19 in Egypt: Uncovered figures or a different situation?Journal of Global Health, 2020
- Coronavirus Disease 2019 (COVID-2019) Infection Among Health Care Workers and Implications for Prevention Measures in a Tertiary Hospital in Wuhan, ChinaJAMA Network Open, 2020
- Evaluation of nine commercial SARS-CoV-2 immunoassaysPublished by Cold Spring Harbor Laboratory ,2020
- Antibody Responses to SARS-CoV-2 in Patients With Novel Coronavirus Disease 2019Clinical Infectious Diseases, 2020
- Preparedness and vulnerability of African countries against importations of COVID-19: a modelling studyThe Lancet, 2020
- Inverse Modelling, Sensitivity and Monte Carlo Analysis inRUsing PackageFMEJournal of Statistical Software, 2010