Synthesis and Transformations of NH‐Sulfoximines
Open Access
- 14 September 2021
- journal article
- review article
- Published by Wiley in Chemistry – A European Journal
- Vol. 27 (69), 17293-17321
- https://doi.org/10.1002/chem.202102619
Abstract
Recent years have seen a marked increase in the occurrence of sulfoximines in the chemical sciences, often presented as valuable motifs for medicinal chemistry. This has been prompted by both pioneering works taking sulfoximines containing compounds into clinical trials and the concurrent development of powerful synthetic methods. This review covers recent developments in the synthesis of sulfoximines concentrating on developments since 2015. This includes extensive developments in both S-N and S-C bond formations. Flow chemistry processes for sulfoximine synthesis are also covered. Finally, subsequent transformations of sulfoximines, particularly in N-functionalization are reviewed, including N–S, N–P, N–C bond forming processes and cyclization reactions.This publication has 210 references indexed in Scilit:
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