Quercetin Synergistically Enhances the Anticancer Efficacy of Docetaxel through Induction of Apoptosis and Modulation of PI3K/AKT, MAPK/ERK, and JAK/STAT3 Signaling Pathways in MDA-MB-231 Breast Cancer Cell Line
Open Access
- 1 December 2021
- journal article
- research article
- Vol. 10 (1), 11-22
- https://doi.org/10.22088/IJMCM.BUMS.10.1.11
Abstract
Docetaxel is widely used in the treatment of metastatic breast cancer. However, its effectiveness is limited due to chemoresistance and its undesirable side effects. The combination of chemotherapeutic agents and natural compounds is an effective strategy to overcome drug resistance and the ensuing inevitable toxicities. Quercetin is a natural flavonoid with ...Keywords
This publication has 55 references indexed in Scilit:
- IL-17A is produced by breast cancer TILs and promotes chemoresistance and proliferation through ERK1/2Scientific Reports, 2013
- Quercetin Increases the Efficacy of Glioblastoma Treatment Compared to Standard Chemoradiotherapy by the Suppression of PI-3-Kinase-Akt PathwayNutrition and Cancer, 2013
- Quercetin Potentiates Doxorubicin Mediated Antitumor Effects against Liver Cancer through p53/Bcl-xlPLOS ONE, 2012
- Functional p53 determines docetaxel sensitivity in prostate cancer cellsThe Prostate, 2012
- Towards Omni-Tomography—Grand Fusion of Multiple Modalities for Simultaneous Interior TomographyPLOS ONE, 2012
- Taxane resistance in breast cancer: Mechanisms, predictive biomarkers and circumvention strategiesCancer Treatment Reviews, 2012
- Silencing Notch-1 induces apoptosis and increases the chemosensitivity of prostate cancer cells to docetaxel through Bcl-2 and BaxOncology Letters, 2012
- Docetaxel-Induced Apoptosis of Human Melanoma Is Mediated by Activation of c-Jun NH2-Terminal Kinase and Inhibited by the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase 1/2 PathwayClinical Cancer Research, 2007
- Mode of action of docetaxel – a basis for combination with novel anticancer agentsCancer Treatment Reviews, 2003
- Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodMethods, 2001