The genetic and epigenetic landscape of early-onset colorectal cancer
- 31 August 2020
- journal article
- review article
- Published by Taylor & Francis Ltd in Colorectal Cancer
- Vol. 9 (3)
- https://doi.org/10.2217/crc-2020-0005
Abstract
Colorectal cancer (CRC) in individuals under the age of 50 is a problem that is increasing in USA and around the world. In this review, we discuss the degree to which early-onset (EO)CRC may be due to unsuspected Lynch syndrome or other inherited germline variants that predispose to cancer, describe the known somatic genetic alterations in EO tumors and discuss alterations in DNA methylation. Approximately 20% of EOCRCs can be attributed to identifiable germline mutations in genes that cause familial cancer syndromes. A variety of other genetic/epigenetic alterations have also been reported. We conclude that this is a heterogeneous problem, that requires a comprehensive analysis of genetic/epigenetic signatures to better understand EOCRC. Various subsets of EOCRCs must be analyzed individually for clues regarding the etiologies and possible specific therapies for this disease.This publication has 59 references indexed in Scilit:
- Signatures of mutational processes in human cancerNature, 2013
- A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal CancerPLOS ONE, 2012
- A repetitive elements perspective in Polycomb epigeneticsFrontiers in Genetics, 2012
- Prevalence of Alterations in DNA Mismatch Repair Genes in Patients With Young-Onset Colorectal CancerClinical Gastroenterology and Hepatology, 2011
- Low Frequency of Lynch Syndrome Among Young Patients With Non-Familial Colorectal CancerClinical Gastroenterology and Hepatology, 2010
- MSH6 and MUTYH Deficiency Is a Frequent Event in Early-Onset Colorectal CancerClinical Cancer Research, 2010
- Aberrant DNA Methylation in Hereditary Nonpolyposis Colorectal Cancer Without Mismatch Repair DeficiencyGastroenterology, 2010
- Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot projectNature, 2007
- Higher Frequency of Diploidy in Young-Onset Microsatellite-Stable Colorectal CancerClinical Cancer Research, 2007
- Clues to the Pathogenesis of Familial Colorectal CancerScience, 1993