Comprehensive assessment and meta-analysis of the association between CTNNB1 polymorphisms and cancer risk
Open Access
- 23 November 2017
- journal article
- research article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 37 (6)
- https://doi.org/10.1042/bsr20171121
Abstract
CTNNB1, encoding β-catenin, is a well-known tumor-related gene in the wnt signaling pathway. It has been reported that CTNNB1 polymorphisms are associated with cancer risk. However, the data were inconsistent. In this article, we conducted a systematic review for the researches related to the association of single nucleotide polymorphisms (SNPs) in CTNNB1 with overall cancer risk. Meanwhile, a series of inclusion and exclusion criteria were set to select articles for quantitative analysis. Consequently, eight case-control studies containing 4388 cases and 4477 controls were included in a meta-analysis of four highly studied CTNNB1 SNPs (rs1798802 A/G, rs4135385 A/G, rs11564475 A/G, and rs2293303 C/T). The association between each SNP and cancer risk was estimated by calculating odds ratios (ORs) and their 95% confidence intervals (95%CIs). The results showed rs1798802 (AA compared with GG: P=0.044, OR=0.72) and rs2293303 (TT compared with CC: P=0.002, OR=2.86; recessive model: P=0.006, OR=2.91; T compared with C: P=0.004, OR=1.19) polymorphisms were associated with overall cancer risk. In stratified analysis, rs4135385 polymorphism was found to elevate the risk in Caucasian or in gastrointestinal cancer subgroup. Additionally, rs2293303 conferred to an increased cancer risk when the source of control groups was hospital-based (HB). In conclusion, the three CTNNB1 SNPs were suggested to have the potential to be novel biomarkers for risk prediction of cancer in overall population or some specific subgroups. Our study could provide research clues for further related investigations.This publication has 24 references indexed in Scilit:
- A systematic review and meta-analysis of the association between long non-coding RNA polymorphisms and cancer riskMutation research. Reviews in mutation research, 2017
- Association of Wnt signaling pathway genetic variants in gallbladder cancer susceptibility and survivalTumor Biology, 2015
- Association of Genetic Polymorphisms in CDH1 and CTNNB1 with Breast Cancer Susceptibility and Patients' Prognosis among Chinese Han WomenPLOS ONE, 2015
- Comprehensive assessment of the association between miRNA polymorphisms and gastric cancer riskMutation research. Reviews in mutation research, 2015
- Association of Single Nucleotide Polymorphisms in Wnt Signaling Pathway Genes with Breast Cancer in Saudi PatientsPLOS ONE, 2013
- Understanding the contribution of synonymous mutations to human diseaseNature Reviews Genetics, 2011
- Wnt/β-Catenin Signaling Enhances Cyclooxygenase-2 (COX2) Transcriptional Activity in Gastric Cancer CellsPLOS ONE, 2011
- Association Analysis of Wnt Pathway Genes on Prostate-Specific Antigen Recurrence After Radical ProstatectomyAnnals of Surgical Oncology, 2009
- Wnt/β-catenin signalingCytokine & Growth Factor Reviews, 2000
- Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer.1999