The tumor cell‐derived matrix of lobular breast cancer: a new vulnerability
Open Access
- 22 February 2021
- journal article
- editorial
- Published by EMBO in EMBO Molecular Medicine
- Vol. 13 (3), e13807
- https://doi.org/10.15252/emmm.202013807
Abstract
Invasive lobular carcinoma (ILC) of the breast is a very common disease. Despite its prevalence, these tumors are relatively understudied. One reason for this is a relative lack of models for ILC. This challenge was addressed by Brisken and colleagues through development of an intraductal injection‐based xenograft system for the study of ERα+ breast cancers, including both ILC and more common invasive ductal carcinoma (IDC; Sflomos et al, 2016). In this issue of EMBO Molecular Medicine, the same group have applied intraductal injection‐based xenografts to identify novel tumor cell‐specific transcriptional signatures in ILC (Sflomos et al, 2021). In doing so they found overexpression of lysyl oxidase‐like 1 (LOXL1) to be both responsible for the frequently seen stiff collagen‐rich extracellular matrix of lobular breast cancer and essential for their robust growth and metastatic dissemination in vivo, thereby identifying a novel therapeutic target.This publication has 9 references indexed in Scilit:
- Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1EMBO Molecular Medicine, 2021
- Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancerNature Communications, 2020
- Exploring Collagen Parameters in Pure Special Types of Invasive Breast CancerScientific Reports, 2019
- E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast CancerCancer Discovery, 2018
- A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone ResponseCancer Cell, 2016
- Comprehensive Molecular Portraits of Invasive Lobular Breast CancerCell, 2015
- Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltrationIntegrative Biology, 2015
- An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situBreast Cancer Research, 2009
- Prospective identification of tumorigenic breast cancer cellsProceedings of the National Academy of Sciences of the United States of America, 2003