Water pollution effect on aquatic organisms and if consumed can affect people's health. These pollutants can be heavy metals such as Cd, Pb, Cr, Hg, and others. Heavy metals have high levels will cause disorders of the kidneys, brain, severe irritation to the skin, can cause diarrhea and even death. The purpose of this paper is to explain physiological mechanisms that occur in the body of gastropods are linked to pollutants in the water environment. Therefore, monitoring the level of pollution a body of water that is alleged to have suffered contamination is very important. Gastropods is one of aquatic animals (Class) used as bio-indicators for this group of animals has a high ability to accumulate heavy metals in their bodies compared to other aquatic animals. The main indicator that can be shown by gastropods are declining abundance and body size. Other indicators are as bioavailability of heavy metals in the soft tissues and shells. The ability of the heavy metal deposits is influenced by environmental factors, body size, weight, and gender. Heavy metals can affect hard, thickness, volume, and color of the shell.