Dual-Mode Imaging System Based on Fe3O4@CuInS2 Core-Shell Structure

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Abstract
本文利用Fe3O4的磁性性质和CuInS2的荧光特性，构建基于Fe3O4@CuInS2的磁共振/荧光双模式成像系统。采用溶剂热法制备具有良好分散性的超顺磁Fe3O4纳米颗粒，利用胶体法合成新型CuInS2/CdS/ZnS核壳量子点，通过表面酰胺键缩合，构建Fe3O4@CuInS2核壳结构。结果表明，Fe3O4@CuInS2复合粒子具有超顺磁性和近红外荧光发射峰，经过表面PEG修饰，能够有效进入细胞，实现磁共振和荧光双模式细胞成像。该系统后续有望应用于医学诊断、药物研究、生物检测等领域，为双模式生物成像提供一个新思路。 This work constructs a dual-mode imaging system with nuclear magnetic resonance and fluores-cence imaging based on the magnetic properties of Fe3O4 and the fluorescence properties of CuInS2. Superparamagnetic Fe3O4 nanoparticles were synthesized by solvothermal method, and SiO2 was loaded on its surface. CuInS2/CdS/ZnS core-shell ternary quantum dots were combined on the surface to form Fe3O4@CuInS2 core-shell structure. The results show that the Fe3O4@CuInS2 composite particles have superparamagnetism and NIR fluorescence emission band. And after surface PEG modification, it could effectively enter the cell and achieve magnetic resonance and fluorescence double-mode cell imaging. The nuclear magnetic resonance/fluorescence dual-mode imaging system based on Fe3O4@CuInS2 is expected to be applied in medical diagnostics, drug re-search, biological detection and other fields, and provide a new idea for dual-mode biological im-aging.